Genomics Services
 
 
NRAS Mutation (Neuroblastoma RAS viral (v-ras) Oncogene Homolog)
NRAS gene encodes for a 21 kDa protein with GTPase activity, and is frequently mutated in a wide variety of solid tumors. NRAS is located on chromosome 1p13.2. NRAS helps in screening individuals with rare colorectal cancers (CRCs) who may respond to anti-EGFR therapies and in screening for individuals with melanoma who may respond to therapy targeted at downstream genes in the MAPK signaling pathway. Mutation identification of tumors aids in the molecular classification of disease subtypes and has guided the development of targeted therapies.

Sample Type

FFPE Tissue: Formalin Fixed Parafin Embedded (FFPE) tissue block with atleast 3-4 sections of tumor tissue. Tissue section should contain >70% tumor content verified by pathologist and should be sent along with 5 H&E stained and 5 unstained slides of tumor tissue.
 
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EGFR (Epidermal Growth Factor Receptor)   |   ALK (Anaplastic lymphoma kinase)
BRAF (B-Raf proto-oncogene, serine/threonine kinase)   |   BRCA1 and BRCA2   |   CHECK2 (Check Point Homolog)
KRAS (Ki-ras2 Kirsten rat sarcoma viral oncogene homolog)   |   Tyrosine Kinase Sensitivity for KIT & PDGFRA
HER2 (Human Epidermal Growth factor Receptor 2) or ERBB2   |   TP53 (Tumor Protein p53)   |   BCR-ABL
Tamoxifen   |   NRAS Mutation   |   Tyrosine Kinase Sensitivity for Abl1 Mutations
HRAS Mutation (Harvey rat sarcoma viral Oncogene Homolog)   |   DPYD Mutation (for 5FU Sensitivity)
MAPK1 Mutation Analysis
 
 
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