Genomics Services
 
 
BCR-ABL
Recommended for CML and ALL

BCR gene (Breakpoint Cluster Region) is located on chromosome 9 and ABL (Abelson Murine Leukemia viral oncogene homolog1) gene is located on chromosome 22. Reciprocal translocation [t(9;22)] results in gene rearrangement producing a fusion gene. This is called Philadelphia chromosome. Presence of this fusion gene is the hallmark cytogenetic event in 90% CML cases and 20% ALL cases. Presence and quantification of BCR ABL fusion gene is important for diagnosis and monitoring of CML. Also presence of Philadelphia chromosome is observed in some ALL cases which are classified as Ph+ ALL. It shows direct association with opting of TKI therapy for ALL patients.

Sample Type

Blood Sample: 5 ml blood in EDTA Vacutainer at 2-8°C.

Bone Marrow Aspirate: 3- 5ml of bone marrow in EDTA vacutainer at 2-8°C
 
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EGFR (Epidermal Growth Factor Receptor)   |   ALK (Anaplastic lymphoma kinase)
BRAF (B-Raf proto-oncogene, serine/threonine kinase)   |   BRCA1 and BRCA2   |   CHECK2 (Check Point Homolog)
KRAS (Ki-ras2 Kirsten rat sarcoma viral oncogene homolog)   |   Tyrosine Kinase Sensitivity for KIT & PDGFRA
HER2 (Human Epidermal Growth factor Receptor 2) or ERBB2   |   TP53 (Tumor Protein p53)   |   BCR-ABL
Tamoxifen   |   NRAS Mutation   |   Tyrosine Kinase Sensitivity for Abl1 Mutations
HRAS Mutation (Harvey rat sarcoma viral Oncogene Homolog)   |   DPYD Mutation (for 5FU Sensitivity)
MAPK1 Mutation Analysis
 
 
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