Genomics Services
 
 
TP53 (Tumor Protein p53)
Recommended for Brain tumor, Colorectal Cancer, Osteosarcoma, Rhabdomyocarcinoma, Adrenocortical Carcinoma etc.

TP53 is gene for cellular tumor protein p53. A protein of human cell that regulates cell cycle and has important function in tumor supression. It is located on short arm of chromosome 7. Function of this gene is linked with control of cell proliferation under normal conditions. Mutations in this gene leads to alteration in function of tumor supressor activity, which results on loss of control over cell division cycle. Somatic mutations in TP53 are common in humans cancers like breast cancers, bladder cancers and in several types of brain tumor, colorectal cancer, osteosarcoma, rhabdomyocarcinoma, adrenocortical carcinoma etc. It is also observed in hereditary cancers such as Li-Fraumeni syndrome.

Sample Type

Blood Sample: 5 ml blood in EDTA Vacutainer at 2-8°C
 
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EGFR (Epidermal Growth Factor Receptor)   |   ALK (Anaplastic lymphoma kinase)
BRAF (B-Raf proto-oncogene, serine/threonine kinase)   |   BRCA1 and BRCA2   |   CHECK2 (Check Point Homolog)
KRAS (Ki-ras2 Kirsten rat sarcoma viral oncogene homolog)   |   Tyrosine Kinase Sensitivity for KIT & PDGFRA
HER2 (Human Epidermal Growth factor Receptor 2) or ERBB2   |   TP53 (Tumor Protein p53)   |   BCR-ABL
Tamoxifen   |   NRAS Mutation   |   Tyrosine Kinase Sensitivity for Abl1 Mutations
HRAS Mutation (Harvey rat sarcoma viral Oncogene Homolog)   |   DPYD Mutation (for 5FU Sensitivity)
MAPK1 Mutation Analysis
 
 
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