Genomics Services
 
 
KRAS (Ki-ras2 Kirsten rat sarcoma viral oncogene homolog)
Recommended for Colorectal cancer, Non Small Cell Lung Cancer and Solid Malignancies

The KRAS gene encodes a small GTPase transductor protein called KRAS in humans. The protein product performs an essential function of signaling and has major role in cell division in normal tissue. KRAS gene is located on human chromosome 12p12.1. A single amino acid substitution is responsible for an activating mutation with implications in various malignancies, including colorectal carcinoma, ductal carcinoma of the pancreas and mucinous adenoma. The presence of KRAS mutations is directly associated with an absence of response to anti-EGFR monoclonal-antibody-based treatments.

Sample Type

FFPE Tissue: Formalin Fixed Parafin Embedded (FFPE) tissue block with atleast 3-4 sections of tumor tissue. Tissue section should contain >70% tumor content verified by pathologist and should be sent along with 5 H&E stained and 5 unstained slides of tumor tissue.

Fresh Tissue: Fresh tissue in tms RNS stabilizer (XGtms-100) provided by Xcelris Labs in sterile leak proof container at -20°C (in Dry Ice)
 
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EGFR (Epidermal Growth Factor Receptor)   |   ALK (Anaplastic lymphoma kinase)
BRAF (B-Raf proto-oncogene, serine/threonine kinase)   |   BRCA1 and BRCA2   |   CHECK2 (Check Point Homolog)
KRAS (Ki-ras2 Kirsten rat sarcoma viral oncogene homolog)   |   Tyrosine Kinase Sensitivity for KIT & PDGFRA
HER2 (Human Epidermal Growth factor Receptor 2) or ERBB2   |   TP53 (Tumor Protein p53)   |   BCR-ABL
Tamoxifen   |   NRAS Mutation   |   Tyrosine Kinase Sensitivity for Abl1 Mutations
HRAS Mutation (Harvey rat sarcoma viral Oncogene Homolog)   |   DPYD Mutation (for 5FU Sensitivity)
MAPK1 Mutation Analysis
 
 
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