Genomics Services
CHECK2 (Check Point Homolog)
Recommended for Breast Cancer and Gastric Cancer

Checkpoint Kinase 2 (CHEK2) is a serine/threonine kinase involved in cell cycle regulation and apoptosis after DNA damage has occurred. It is located on the long (q) arm of chromosome 22 . Activation of CHEK2 as a result of DNA damage inhibits a cell from initiating mitosis. Mutation in this gene is associated with certain CHECK2 related cancers. It is a prognostic marker for breast cancer and gastric cancer. Implications of this mutation is also observed in cancers of colon, kidney, prostrate and thyroid.

Sample Type

Blood Sample: 5 ml blood in EDTA Vacutainer at 2-8°C
Brochure           inquiry
EGFR (Epidermal Growth Factor Receptor)   |   ALK (Anaplastic lymphoma kinase)
BRAF (B-Raf proto-oncogene, serine/threonine kinase)   |   BRCA1 and BRCA2   |   CHECK2 (Check Point Homolog)
KRAS (Ki-ras2 Kirsten rat sarcoma viral oncogene homolog)   |   Tyrosine Kinase Sensitivity for KIT & PDGFRA
HER2 (Human Epidermal Growth factor Receptor 2) or ERBB2   |   TP53 (Tumor Protein p53)   |   BCR-ABL
Tamoxifen   |   NRAS Mutation   |   Tyrosine Kinase Sensitivity for Abl1 Mutations
HRAS Mutation (Harvey rat sarcoma viral Oncogene Homolog)   |   DPYD Mutation (for 5FU Sensitivity)
MAPK1 Mutation Analysis
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