Genomics Services
BRAF (B-Raf proto-oncogene, serine/threonine kinase)
Recommended for Papillary Thyroid Carcinoma (PTC) and Melanomas

BRAF is a human proto-oncogene, which is located on chromosome 7q34 and it synthesizes protein BRAF commonly known as serine/threonine-protein kinase BRAF. This protein is important are involved in cell growth & differentiation. Mutated gene is observed in Papillary Thyroid Carcinoma (PTC) and Melanomas occurring in approximately 45% of tumors. Somatic mutations in BRAF commonly occur in the cancer types that harbor RAS mutations. So if KRAS mutation is present then chances of occurrence of BRAF mutation increases. Presence of BRAF mutations have important therapeutic implications.

Sample Type

FFPE Tissue: Formalin Fixed Parafin Embedded (FFPE) tissue block with atleast 3-4 sections of tumor tissue. Tissue section should contain >70% tumor content verified by pathologist and should be sent along with 5 H&E stained and 5 unstained slides of tumor tissue.

Fresh Tissue: Fresh tissue in tms RNS stabilizer (XGtms-100) provided by Xcelris Labs in sterile leak proof container at -20°C (in Dry Ice)
Brochure           inquiry
EGFR (Epidermal Growth Factor Receptor)   |   ALK (Anaplastic lymphoma kinase)
BRAF (B-Raf proto-oncogene, serine/threonine kinase)   |   BRCA1 and BRCA2   |   CHECK2 (Check Point Homolog)
KRAS (Ki-ras2 Kirsten rat sarcoma viral oncogene homolog)   |   Tyrosine Kinase Sensitivity for KIT & PDGFRA
HER2 (Human Epidermal Growth factor Receptor 2) or ERBB2   |   TP53 (Tumor Protein p53)   |   BCR-ABL
Tamoxifen   |   NRAS Mutation   |   Tyrosine Kinase Sensitivity for Abl1 Mutations
HRAS Mutation (Harvey rat sarcoma viral Oncogene Homolog)   |   DPYD Mutation (for 5FU Sensitivity)
MAPK1 Mutation Analysis
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